Antacid medication inhibits digestion of dietary proteins and causes food allergy

Antacid medication inhibits digestion of dietary proteins and causes food allergy: A fish allergy model in balb/c mice
-Eva Untersmayr, MD, et al.

Journal of Allergy and Clinical Immunology,Volume 112, Issue 3, September 2003, Pages 616–623

Excerpt:

• When antacid medication impairs the gastric digestion, IgE synthesis toward novel dietary proteins is promoted, leading to food allergy.

Idiopathic eosinophilic esophagitis is associated with a TH2-type allergic inflammatory response

Idiopathic eosinophilic esophagitis is associated with a TH2-type allergic inflammatory response
-Alex Straumann, MDa, et al.

Journal of Allergy and Clinical Immunology

Volume 108, Issue 6, December 2001, Pages 954–961

"IEE is a selective inflammatory response of the esophagus. T cells, IL-5, eosinophils, and IgE-mediated mechanisms appear to be involved, giving rise to the possibility that allergic reactions might play a role in the pathogenesis of the disease."

Atopic syndrome

• "Atopic syndrome is a predisposition toward developing certain allergic hypersensitivity reactions. Atopy may have a hereditary component, although contact with the allergen must occur before the hypersensitivity reaction can develop."
•  Many EE patients suffer from concurrent autoimmune and allergic disease.
• Patients with atopy usually develop what is referred to as the “allergic triad” of symptoms, i.e., eczema (atopic dermatitis), hay fever (allergic rhinitis), and allergy-induced asthma (allergic asthma).
• They also have a tendency to have food allergies, and other symptoms characterized by their hyperallergic state. For example, eosinophilic esophagitis is found associated with atopic allergies.
• Although atopy has various definitions, in general, it is defined by the presence of elevated levels of total and allergen-specific IgE in the serum, leading to positive skin-prick tests to common allergens.
• There is a strong genetic predisposition toward atopic allergies, especially on the maternal side.

-Atopy - Wikipedia, the free encyclopedia